FOXO4-DRI Peptide 10MG

FOXO4-DRI Peptide is a synthetic retro-inverso peptide that has attracted considerable interest in laboratory research involving cellular senescence, FOXO4-p53 signaling and senolytic mechanisms. Unlike conventional peptides composed of L-amino acids, FOXO4-DRI incorporates D-amino-acid chemistry in a retro-inverso configuration, making it a particularly interesting subject for peptide structure, stability and biological-interaction studies.

At Peptanovia, FOXO4-DRI Peptide 10MG is presented as a research-grade laboratory material intended for qualified researchers, biotechnology laboratories, academic institutions and other organizations conducting legitimate scientific investigations.

Researchers interested in exploring the wider peptide catalog can visit the Peptanovia homepage.

What Is FOXO4-DRI Peptide?

FOXO4-DRI stands for Forkhead Box O4 D-Retro-Inverso peptide. It was designed around a region of the FOXO4 protein involved in its interaction with p53.

Research has focused on the FOXO4-p53 interaction because FOXO4 can participate in mechanisms that help maintain the survival of senescent cells. FOXO4-DRI has therefore been investigated as an experimental peptide capable of interfering with this interaction.

The compound is not simply a conventional FOXO4 fragment. Its retro-inverso architecture uses D-amino acids arranged in reversed sequence orientation, creating a distinct molecular configuration that researchers can investigate in relation to peptide stability, target interaction and biological activity.

PubChem lists FOXO4-DRI under the synonym FOXO4-DRI TFA salt and provides a molecular formula of C228H388N86O64 and a molecular weight of approximately 5358 g/mol for the listed compound. Because salt forms and analytical specifications can differ between preparations, researchers should always verify the lot-specific product documentation.

FOXO4-DRI and Cellular Senescence Research

One of the primary reasons FOXO4-DRI has become interesting to researchers is its relationship with cellular senescence.

Senescent cells are cells that have permanently or persistently stopped proliferating but remain metabolically active. Their accumulation and associated signaling pathways are widely investigated in aging biology and disease research.

Experimental studies have examined whether disrupting the FOXO4-p53 interaction can promote apoptosis in senescent cells. In laboratory and animal models, FOXO4-DRI has been investigated for its potential senolytic activity.

This makes FOXO4-DRI particularly relevant to researchers studying:

• Cellular senescence
• Senolytic mechanisms
• FOXO signaling
• p53 signaling
• Apoptosis
• Protein-protein interactions
• Aging biology
• Molecular pharmacology
• Peptide engineering
• Cell biology

FOXO4-DRI Peptide Research Applications

FOXO4-DRI can be relevant to several areas of experimental research.

Cellular Senescence Studies

Researchers can investigate FOXO4-DRI in cellular models designed to examine senescent-cell biology and the molecular pathways associated with cellular survival.

Published research has investigated FOXO4-DRI in senescent human chondrocyte models, where researchers examined selective removal of senescent cells following peptide treatment.

FOXO4-p53 Interaction Research

FOXO4-DRI is particularly valuable as a research tool for studying the interaction between FOXO4 and p53.

Investigators can use experimental systems to examine how disruption of this protein interaction influences downstream cellular processes.

Senolytic Research

FOXO4-DRI has been investigated as an experimental senolytic peptide. This research area examines compounds capable of selectively affecting senescent cells.

Importantly, laboratory findings should not be interpreted as evidence that FOXO4-DRI is an approved anti-aging treatment or established human therapeutic.

Apoptosis Research

Because the FOXO4-p53 pathway is connected with cellular survival and apoptosis, FOXO4-DRI can be studied in experimental models investigating programmed cell death.

Recent research has examined FOXO4-DRI in endothelial-cell senescence and reported effects involving p53, BAX and caspase-3 signaling in experimental models.

Aging Biology

FOXO4-DRI is also being investigated within broader experimental research into aging and age-associated cellular changes.

Recent animal research has examined FOXO4-DRI in models involving brain aging and cognitive decline, while other studies have explored its relationship with reproductive aging and senescent Leydig cells. These findings remain experimental and should not be presented as established human treatment outcomes.

FOXO4-DRI Peptide 10MG Product Details

Product: FOXO4-DRI Peptide

Quantity: 10MG

Category: Research peptide

Intended application: Laboratory and scientific research

Peptide type: Synthetic retro-inverso peptide

Research areas: Cellular senescence, FOXO4-p53 signaling, senolytic research, apoptosis and molecular biology

Format: Researchers should verify the specific supplied presentation, salt form, purity and analytical documentation for each batch.

Research status: Experimental

The 10MG designation refers to the stated amount of peptide material in the product. It should not be interpreted as a recommended dose, treatment quantity or clinical administration instruction.

Research Grade FOXO4-DRI

When purchasing research peptides, researchers should look beyond the product name and quantity.

A professional laboratory may require detailed information covering:

• Peptide identity
• Sequence information
• Molecular weight
• Purity
• Salt or counter-ion form
• Batch identification
• Certificate of Analysis
• HPLC analysis
• Mass spectrometry
• Appearance and physical form
• Storage information
• Handling requirements
• Manufacturing specifications

Analytical documentation is especially important for experiments where reproducibility between batches matters.

Why Peptide Purity Matters

Peptide research often depends on accurate characterization and consistent experimental materials.

Impurities can complicate analytical results, introduce unexpected variables and make it more difficult to reproduce experimental observations. For this reason, researchers should review available analytical documentation before incorporating FOXO4-DRI into a laboratory workflow.

HPLC can provide information about chromatographic purity, while mass spectrometry can assist with molecular identification. Researchers should interpret these analytical results according to their own laboratory quality standards.

FOXO4-DRI for Research Laboratories

FOXO4-DRI may be relevant to organizations working across several scientific disciplines.

Potential research users include:

• Academic laboratories
• Biotechnology companies
• Pharmaceutical research teams
• Molecular biology laboratories
• Cellular biology researchers
• Aging research laboratories
• Peptide research groups
• Contract research organizations
• Analytical laboratories
• Preclinical research teams

The specific suitability of FOXO4-DRI depends on the research question, experimental model and validated laboratory methodology.

FOXO4-DRI and Senolytic Research

The term senolytic describes an area of research focused on selectively targeting senescent cells.

FOXO4-DRI has been investigated in this context because of its ability to interfere with FOXO4-p53 interactions. Studies have reported experimental effects in different cellular and animal models, including work involving chondrocytes and endothelial cells.

However, it is important to distinguish between experimental senolytic activity and a clinically validated senolytic therapy. FOXO4-DRI remains a research compound and should not be represented as an established treatment for aging, disease or any specific medical condition.

Bulk Research Peptide Supply

For laboratories conducting larger projects, bulk procurement can simplify research-material management and help maintain consistency between experiments.

When evaluating larger FOXO4-DRI requirements, researchers may consider:

• Required quantity
• Purity specification
• Batch documentation
• Analytical testing
• Packaging
• Storage requirements
• Shipping conditions
• Lot traceability
• Research-use documentation

For larger research programs, laboratories should confirm the exact specifications required by their internal quality-control procedures before ordering.

FOXO4-DRI Research: What the Science Shows

The scientific interest surrounding FOXO4-DRI is based largely on experimental research rather than established clinical medicine.

Studies have investigated FOXO4-DRI in senescent human chondrocytes, endothelial-cell models and animal models of aging-related biological changes.

This makes FOXO4-DRI an interesting compound for researchers studying the molecular biology of cellular senescence and the FOXO4-p53 pathway.

At the same time, the results from cellular and animal research should not be extrapolated directly to human therapeutic outcomes.

Research Use Only

FOXO4-DRI Peptide 10MG should be presented and handled as a research-use material. It is not an FDA-approved drug, dietary supplement or established treatment for aging, cancer, inflammation, cardiovascular disease, neurological conditions or other human diseases.

The information on this page is intended to describe the compound’s research relevance and laboratory applications, not to provide medical advice, dosing instructions or instructions for administration to humans or animals.

Researchers should follow applicable laws, institutional requirements, laboratory safety procedures and the documentation supplied with the specific product.

Order FOXO4-DRI Peptide 10MG for Research

FOXO4-DRI represents an important experimental tool within contemporary research into cellular senescence, FOXO4-p53 signaling and senolytic peptide mechanisms.

For laboratories seeking FOXO4-DRI Peptide 10MG for legitimate scientific research, product identity, analytical specifications, purity and batch documentation should be evaluated before purchase.

Explore the broader research peptide selection through the Peptanovia homepage and review the specifications relevant to your laboratory’s research requirements.

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